July 15, 1999 Media Contact: Kate
Deely (619) 543-6163
UCSD MEDICAL CENTER PATIENTS WHO SHARE LIVER MEET
Both Patients are Recovering Nicely
Sixty-two-year-old Harold Turner and 18-month-old Cesar Sepulveda, who were
transplanted with portions of the same liver from a deceased donor last week, met for the
first time today. Both patients are recovering quite well after undergoing the county's
first split-liver transplant.
This procedure, performed on July 7, was the first split-liver transplant to be
performed south of Los Angeles, and Cesar's transplant was only the county's second
pediatric liver transplant. UCSD Healthcare surgeons and physicians said the patients are
recovering better then anticipated. "Both of these patients will be discharged much
sooner then expected," said Ajai Khanna, M.D., UCSD Healthcare's director of
pediatric abdominal transplantation and transplantation research, who was the lead surgeon
on Cesar's transplant.
A little more then a week after the surgeries, Dr. Khanna and his colleague, Marquis
Hart, M.D., UCSD Healthcare director of abdominal transplantation surgery and lead surgeon
on Turner's transplant, introduced their two patients and their families. Feeling a
kindred bond, Turner and his wife Shirley presented the little boy with a stuffed animal.
"We definitely feel a connection with Cesar," Shirley said. "We have been
just as worried about him as we have been for ourselves."
Splitting livers involves dividing a liver into two transplantable segments. A child is
transplanted with the left lateral lobe, the smallest of the livers three lobes
which makes up about 10 to 15 percent of the liver. The larger segment is transplanted
into the adult.
As the region's first split-liver transplant, this landmark procedure has proven even
more remarkable. "Normally, a pediatric liver transplant patient is not ready for
discharge for at least two weeks, but Cesar is doing extremely well and his mother is
quite adept at administering his medications, which is key to a transplant patient's
recovery," said Dr. Khanna, who brought the expertise of split-liver transplant to
UCSD from the University of Pittsburgh School of Medicine and Children's Hospital of
Pittsburgh.
Even without the full liver, Turner is doing better then he expected, according to both
his doctors and his wife. Turner, a resident of Escondido who had been waiting for a liver
transplant for about a year and a half, was suffering from hepatitis C which evolved into
pulmonary hepato syndrome, a complication of liver disease which affects oxygenation of
the lungs.
"We had no qualms about Harold getting only a portion of the liver as opposed to
the whole thing," Shirley said. "We had incredible faith in this great team at
UCSD and we know that split-liver transplants have worked successfully for other
people."
"Besides, there was no way we would not have shared this liver with Cesar,"
Shirley adds. "We could not look at his sweet face and say no. Harold doesn't need
all of it to survive and Cesar only needs a little of it, and now they have both gotten a
second chance at life from one organ."
There are many other children out there like Cesar who are waiting for livers; some
dont make it. Adults receive most of the organs, unless the livers are too small to
work in adults. According to Dr. Khanna, there were 1,626 pediatric patients (aged 1 month
to 17 years) on the United Network of Organ Sharing waiting list for liver transplantation
in 1997. On average, 75 children die each year waiting for a liver.
"By dividing a healthy liver into two parts, the number of liver transplants
performed could double," said Hart. "We anticipate that this procedure will help
address the organ shortage. We can continue to give adults the hope that comes from a
transplant and offer the same hope to many more children."
UCSD Healthcare now joins only about a dozen medical centers nationwide performing
split-liver transplants. The procedure has been successfully performed in the United
States for a little more than a decade. In 1998, there were 138 transplants in the United
States involving split livers. In 1988, there were only 16.