UC San Diego News Center


News Archive - Heather Buschman, PhD

  • Machine Learning Algorithm Can’t Distinguish These Lab Mini-Brains from Preemie Babies

    Nine-month-old brains-in-a-dish and the brains of premature newborn babies generate similar electrical patterns, as captured by electroencephalogram (EEG) — the first time such brain activity has been achieved in a cell-based laboratory model.

  • Popular Pain Medication Associated with Greater Risk of Hypoglycemia

  • Single Enzyme Helps Drive Inflammation in Mice, Provides Target for New Sepsis Drugs

    UC San Diego researchers discovered that removing a single enzyme in mice dramatically boosts survival from sepsis, an often fatal over-reaction of the immune system to infection. The finding provides a new and unexpected therapeutic target for new drug development.

  • Adding MS Drug to Targeted Cancer Therapy May Improve Glioblastoma Outcomes

    The multiple sclerosis drug teriflunomide, paired with targeted cancer therapy, markedly shrinks patient-derived glioblastomas grown in mice by reaching stem cells at the tumor’s root, according to a new UC San Diego School of Medicine study published in Science Translational Medicine.

  • Promising Clinical Trial Results for Drug for Rare Disease in Which Patients Can’t Eat Fat

    In a Phase III clinical trial, the drug volanesorsen significantly reduced blood fat (triglyceride) levels in participants with a rare disease called familial chylomicronemia syndrome; finding could also help inform better prevention methods and treatments for many types of heart disease.

  • Protein Clumps in ALS Neurons Provide Potential Target for New Therapies

    UC San Diego School of Medicine researchers identified chemical compounds that prevent stress-induced clumping of TDP-43 protein in ALS motor neurons grown in the lab — a starting point for new ALS therapeutics.

  • Zebrafish Help Researchers Explore Alternatives to Bone Marrow Donation

    UC San Diego researchers discover new role for epidermal growth factor receptor in blood stem cell development, a crucial key to being able to generate them in the laboratory, and circumvent the need for bone marrow donation.

  • Personalized “Eye-in-a-Dish” Models Reveal Genetic Underpinnings of Macular Degeneration

    Using stem cells derived from six people, UC San Diego School of Medicine researchers recapitulated retinal cells in the lab. This “eye-in-a-dish” model allowed them to identify genetic variants that cause age-related macular degeneration, a common cause of vision loss.

  • Movement Toward a Poop Test for Liver Cirrhosis

    In a study of people with nonalcoholic fatty liver disease and their twins and other close relatives, UC San Diego researchers were able to diagnose liver cirrhosis simply by analyzing a person’s stool microbes.