UC San Diego study suggests multisystem inflammatory syndrome in children (MIS-C), a rare condition associated with COVID-19, is not caused by abnormal T cell response to COVID-19 virus as previously hypothesized.
In three Science papers, UC San Diego and UC San Francisco researchers mapped out how hundreds of gene mutations involved in cancer affect the discrete groups of proteins that are the ultimate actors behind the disease. The work points the way to identifying new precision treatments.
UC San Diego School of Medicine researchers will receive $6.4 million in National Institutes of Health grant funding to study how external signals and genetic variations influence the behavior of one cell type in particular: insulin-producing beta cells in the pancreas.
Lab studies reveal protein HSP27’s role in blood vessel leakage, opening the possibility that therapeutically dialing its activity up or down might stabilize patients with sepsis.
UC San Diego researchers developed first-of-their-kind lung organoids that include all cell types that make up the organ, allowing for “Phase 0” testing of new treatments for respiratory infections such as COVID-19.
Researchers identified 579 locations in the human genome associated with a predisposition to self-regulation-related behaviors, such as addiction. With data from 1.5 million people of European descent, the effort is one of the largest genome-wide association studies to date.
Stem cell models derived from people with specific genomic variation recapitulate aspects of their autism spectrum disorder, providing a valuable model to study the condition and look for therapeutic interventions.
Part of UC San Diego’s Return to Learn program, wastewater screening helped prevent outbreaks by detecting 85 percent of cases early, allowing for timely testing, contact tracing and isolation.
UC San Diego studies using human cell lines and tumors grown in mice provide early evidence that inhibiting RNA-binding proteins, a previously overlooked family of molecules, might provide a new approach for treating some cancers.
UC San Diego School of Medicine researchers discovered gene expression patterns associated with pandemic viral infections, providing a map to help define patients’ immune responses, measure disease severity, predict outcomes and test therapies — for current and future pandemics.