UC San Diego School of Medicine researchers identified several genetic switches, or transcription factors, that determine whether or not liver cells produce collagen — providing a new therapeutic target for liver fibrosis.
Two different UC San Diego research teams identified the same molecule — αvβ5 integrin — as Zika virus’ key to brain cell entry. They found ways to take advantage of the integrin to both block Zika virus from infecting cells and turn it into something good: a way to shrink brain cancer stem cells.
UC San Diego School of Medicine researchers have discovered how a new immune system works to protect bacteria from phages, viruses that infect bacteria — new information that could be leveraged to improve treatment of multidrug-resistant bacterial infections by refining phage therapy.
In a UC San Diego study, rats with spinal cord injuries experienced a three-fold increase in motor activity when treated with neural progenitor cells that had been pre-conditioned with a modified form of tPA, a drug commonly used to treat non-hemorrhagic stroke.
People with cystic fibrosis who carry genetic variants that lower RNF5 gene expression have more mutant CFTR protein on cell surfaces. Even if the CFTR protein isn’t fully functional, it’s better than none, and may explain why some with cystic fibrosis are less prone to infection than others.
According to a new Cell study, extra DNA scooped up and copied alongside cancer-causing genes helps keep tumors going — elements that could represent new drug targets for brain tumors and other cancers notoriously difficult to treat.
UC San Diego researchers linked a gut bacteria toxin to worse clinical outcomes in patients with alcoholic liver disease, and discovered that treatment with bacteriophages clears the bacteria and eliminates the disease in mice.
In the largest and most diverse genetic study of PTSD to date, scientists from UC San Diego School of Medicine and more than 130 institutions in the Psychiatric Genomics Consortium found that genetics accounts for five to 20 percent of the variability in PTSD risk following a traumatic event.
UC San Diego researchers investigated how a type of immune cell called a macrophage becomes specialized to the liver. Their study, published October 3, 2019 in Immunity, sets the stage for understanding how macrophage specialization gets disrupted by — or contributes to — liver disease.
A small genetic study, published September 30, 2019 in Nature Genetics, identified a protein linked to many genetic variants that affect heart function. Researchers are expanding the model to other organ systems and at larger scales to create a broader understanding of genes and proteins involved.