In a Phase III clinical trial, the drug volanesorsen significantly reduced blood fat (triglyceride) levels in participants with a rare disease called familial chylomicronemia syndrome; finding could also help inform better prevention methods and treatments for many types of heart disease.
UC San Diego School of Medicine researchers identified chemical compounds that prevent stress-induced clumping of TDP-43 protein in ALS motor neurons grown in the lab — a starting point for new ALS therapeutics.
UC San Diego researchers discover new role for epidermal growth factor receptor in blood stem cell development, a crucial key to being able to generate them in the laboratory, and circumvent the need for bone marrow donation.
Using stem cells derived from six people, UC San Diego School of Medicine researchers recapitulated retinal cells in the lab. This “eye-in-a-dish” model allowed them to identify genetic variants that cause age-related macular degeneration, a common cause of vision loss.
In a study of people with nonalcoholic fatty liver disease and their twins and other close relatives, UC San Diego researchers were able to diagnose liver cirrhosis simply by analyzing a person’s stool microbes.
When she was first transitioning from postdoctoral trainee to assistant professor in the UC San Diego School of Medicine, María Marquine, originally from Uruguay, found the many types of faculty—tenure-track, adjunct, in-residence, clinical and so on—confusing. So too were the “rules” for promotion…
Researchers at UC San Diego School of Medicine generated a new mouse model that mimics human acne for the first time, and used it to validate the concept of “good” and “bad” acne bacteria and introduce new possibilities for targeted treatments and vaccines.
Mining a large database of adverse reactions to medications, UC San Diego researchers found that people who took proton pump inhibitors (e.g., Prilosec, Nexium) for heartburn and acid reflux were more likely to experience kidney disease than people who took other forms of antacid.
In a randomized, controlled pilot trial published February 13, 2019 in PLOS ONE, UC San Diego School of Medicine researchers found that participants pre-treated with noninvasive vagus nerve stimulation experienced less pain after heat stimulus than mock-treated participants.