UC San Diego researchers discovered that the SARS-CoV-2 virus can’t grab hold of cell receptor ACE2 without a carbohydrate called heparan sulfate, which is also found on lung cell surfaces — disrupting that interaction with a repurposed drug may help treat COVID-19.
UC San Diego researchers demonstrate that one dose of their version of CRISR gene editing can chew up toxic RNA and almost completely reverse symptoms in a mouse model of myotonic dystrophy, a type of adult-onset muscular dystrophy.
An elusive protein that many consider the key of fully understanding the causes of genetic Parkinson’s disease has come much more clearly into focus. Impacting millions around the world, Parkinson’s is a neurological disorder that progressively attacks motor functions.
UC San Diego researchers discovered that people with an inactive RNA-editing enzyme respond better to cancer immunotherapy, and inhibitors of the enzyme help mice with difficult-to-treat cancers live longer.
By analyzing the FDA database of adverse drug effects, UC San Diego researchers discovered that people who received Botox injections — not just in the forehead — reported depression significantly less often than patients undergoing different treatments for the same conditions.
By inhibiting the molecule AKT, UC San Diego researchers favor the culture of human spermatogonial stem cells in the lab, a first step toward lab-produced sperm as a treatment for male infertility.
UC San Diego researchers have discovered that a single treatment to inhibit a gene called PTB in mice converts native astrocytes, brain support cells, into neurons that produce the neurotransmitter dopamine. As a result, the mice’s Parkinson’s disease symptoms disappear.
UC San Diego researchers uncovered in mice how IRE1α, a molecule involved in cells’ response to stress, determines whether macrophages promote inflammation in the tumor microenvironment. Inflammation is known to promote tumor growth, making IRE1α an attractive target for drug development.
Ruth S. Waterman, MD, has been named chair of the Department of Anesthesiology at University of California San Diego School of Medicine and UC San Diego Health.
Program makes COVID-19 testing available to thousands of students in effort to track the novel coronavirus and better position the campus to resume in-person activities in the fall.