In a study published January 17, 2019 in Translational Psychiatry, researchers at University of California San Diego School of Medicine describe how, in a novel mouse model, epigenetic regulation negatively impacts a downstream gene specifically involved in neurodevelopment and associated behaviors.
Using induced pluripotent stem cell-derived neurons from Alzheimer’s patients, UC San Diego researchers say cholesteryl esters — the storage product for excess cholesterol within cells — act as regulators of the protein tau, providing a new druggable target for the disease.
Early adult general cognitive ability is a stronger predictor of cognitive function and reserve later in life than other factors, such as higher education, occupational complexity or engaging in late-life intellectual activities.
3D printed implants could one day help restore neural connections and lost motor function in patients with spinal cord injury. The implants, developed by engineers and neuroscientists at the University of California San Diego, are soft bridges that guide new nerve cells to grow across the site at which…
For the first time, researchers at University of California San Diego have used rapid 3D printing technologies to create a spinal cord, then successfully implanted that scaffolding, loaded with neural stem cells, into sites of severe spinal cord injury in rats.
In a new study using a mouse model, researchers at University of California San Diego School of Medicine suggest that long-term postpartum weight gain may be due not so much to retained fat as to reprogramming of maternal energy metabolism.
FDA approves first U.S. clinical trial of an intravenously administered bacteriophage-based therapy to treat resistant bacterial infections.
UC San Diego researchers have found a stem cell enzyme copy edits more than 20 tumor types, providing new therapeutic target for preventing cancer cell resistance to chemotherapy and radiation.
Moderate to severe loneliness can persist across adult lifespans, but UC San Diego School of Medicine researchers found it is particularly acute in three age periods: late-20s, mid-50s and late-80s. Wisdom proved a protective factor.
UC San Diego researchers join national effort to better understand human immune system as part of new Allen Institute of Immunology.