UC San Diego School of Medicine researchers discovered that the enzyme RNA polymerase II recognizes and transcribes artificially added base pairs in genetic code, a new insight that could help advance the development of new vaccines and medicines.
Researchers identify molecular mechanism for the anti-inflammatory activity of diabetes drug metformin and, in mouse studies, say it prevents lung inflammation in animals infected with SARS-CoV-2, the virus that causes COVID-19.
Researchers have created to novel biobanks of diverse tissues from animals to further explore the biological bases and consequences of addiction to cocaine and oxycodone.
UC San Diego researchers found that the chemical inhibitor K777 reduces the coronavirus’ ability to infect cell lines by blocking human enzyme cathepsin L; clinical trials are underway.
By summer 2020, well into the COVID-19 pandemic, Nicaragua’s hospitals were full of patients with respiratory infections. Doctors and nurses were dying. The health system was collapsing. Yet the government has consistently downplayed the COVID-19 pandemic.
UC San Diego researchers discovered that patient survival from sepsis is associated with higher platelet counts, and identified two currently available drugs that protect these blood cells and improve survival in mice with sepsis.
By analyzing the FDA database of adverse drug effects, UC San Diego researchers discovered that people who received Botox injections — not just in the forehead — reported depression significantly less often than patients undergoing different treatments for the same conditions.
SDSC's Sherlock Division has expanded its multi-Cloud solution, Sherlock Cloud, to include the Google Cloud Platform (GCP) in addition to AWS and Microsoft Azure.
UC San Diego researchers recently created a pharmacophore model and conducted data mining of the conformational database of FDA-approved drugs that identifies 64 compounds as potential inhibitors of the COVID-19 protease.
The San Diego Supercomputer Center at UC San Diego is providing priority access to its high-performance computer systems and other resources to researchers advancing our understanding of the virus and efforts to develop an effective vaccine in as short a time as possible.