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News Archive - Heather Buschman

State Stem Cell Agency Awards $4M for Blood Cancer Immunotherapy at UC San Diego

November 24, 2021

The California Institute for Regenerative Medicine (CIRM) approved a $4.1 million grant to enable University of California San Diego School of Medicine researchers to advance a new chimeric antigen receptor (CAR) T-cell therapy from the laboratory into the clinic.

We Might Not Know Half of What’s in Our Cells, New AI Technique Reveals

November 24, 2021

Artificial intelligence-based technique reveals previously unknown cell components that may provide new clues to human development and disease.

Selective, Toxin-Bearing Antibodies Could Help Treat Liver Fibrosis

July 12, 2021

UC San Diego researchers discovered that immunotoxins targeting the protein mesothelin prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis, in mouse models of human disease.

How Cells “Read” Artificial Ingredients Tossed into Genetic Recipe

June 17, 2021

UC San Diego School of Medicine researchers discovered that the enzyme RNA polymerase II recognizes and transcribes artificially added base pairs in genetic code, a new insight that could help advance the development of new vaccines and medicines.

Evolution May Be to Blame for High Risk of Advanced Cancers in Humans

December 8, 2020

Compared to chimpanzees, our closest evolutionary cousins, humans are particularly prone to developing advanced carcinomas — the type of tumors that include prostate, breast, lung and colorectal cancers — even in the absence of known risk factors, such as genetic predisposition or tobacco use.

DrugCell: New Experimental AI Platform Matches Tumor to Best Drug Combo

October 22, 2020

UC San Diego researchers use experimental artificial intelligence system called DrugCell to predict the best approach to treating cancer. Only 4 percent of all cancer therapeutic drugs under development earn final approval by the U.S. Food and Drug Administration (FDA).

Why Young and Female Patients Don’t Respond as Well to Cancer Immunotherapy

August 17, 2020

UC San Diego researchers discovered that tumor cells in younger and female patients accumulate cancer-causing mutations that are more poorly presented to the immune system, better enabling tumors to escape detection and clearance.

In Mice, Eliminating Damaged Mitochondria Alleviates Chronic Inflammatory Disease

April 11, 2019

Treatment with a choline kinase inhibitor prompts immune cells to clear away damaged mitochondria, thus reducing NLRP3 inflammasome activation and preventing inflammation

In Mice, Eliminating Damaged Mitochondria Alleviates Chronic Inflammatory Disease

April 11, 2019

Treatment with a choline kinase inhibitor prompts immune cells to clear away damaged mitochondria, thus reducing NLRP3 inflammasome activation and preventing inflammation

The Rising Price of Medicare Part D’s 10 Most Costly Medications

July 5, 2018

Researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego have found that the cost for the 10 “highest spend” medications in Medicare Part D — the U.S. federal government’s primary prescription drug benefit for older citizens — rose almost one-third between 2011 and 2015, even as the number of persons using these drugs dropped by the same amount.
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