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News Archive - Scott LaFee

Transcranial Electrical Stimulation Shows Promise for Treating Mild Traumatic Brain Injury

September 28, 2017

Using a form of low-impulse electrical stimulation to the brain, documented by neuroimaging, researchers at the University of California San Diego School of Medicine, Veterans Affairs San Diego Healthcare System (VASDHS) and collaborators elsewhere, report significantly improved neural function in participants with mild traumatic brain injury (TBI).

Researchers Develop New Tool to Assess Individual’s Level of Wisdom

September 20, 2017

Researchers at University of San Diego School of Medicine have developed a new tool called the San Diego Wisdom Scale (SD-WISE) to assess an individual’s level of wisdom, based upon a conceptualization of wisdom as a trait with a neurobiological as well as psychosocial basis.

People with Schizophrenia Left Out of Longevity Revolution

September 15, 2017

A team of researchers at University of California San Diego School of Medicine and Veterans Affairs San Diego Healthcare System analyzed published longitudinal studies of mortality in schizophrenia that met their strict research criteria and found that the mean standardized mortality ratio – a measure of the mortality rate in schizophrenia – has increased 37 percent from pre-1970s studies to post-1970s studies.

Zika Virus Targets and Kills Brain Cancer Stem Cells

September 5, 2017

In developing fetuses, infection by the Zika virus can result in devastating neurological damage, most notably microcephaly and other brain malformations. In a new study, published today in The Journal of Experimental Medicine, researchers at the University of California San Diego School of Medicine and Washington University School of Medicine in St. Louis report the virus specifically targets and kills brain cancer stem cells.

It’s Not a Rat’s Race for Human Stem Cells Grafted to Repair Spinal Cord Injuries

August 28, 2017

More than one-and-a-half years after implantation, researchers at University of California San Diego School of Medicine and the San Diego Veterans Administration Medical Center report that human neural stem cells (NSCs) grafted into spinal cord injuries in laboratory rats displayed continued growth and maturity, with functional recovery beginning one year after grafting.

State’s Stem Cell Agency Awards $18.2 Million Grant for B Cell Cancer Clinical Trial

August 24, 2017

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine (CIRM) today unanimously approved an $18.29 million grant to University of California San Diego School of Medicine researchers to fund a phase Ib/IIa clinical trial of a novel combination drug therapy for B-cell cancers.

Novel Stem Cell-Derived Model Created of Inflammatory Neurological Disorder

August 10, 2017

An international team of scientists, led by University of California San Diego School of Medicine researchers, has created a human stem cell-based model of a rare, but devastating, inherited neurological autoimmune condition called Aicardi-Goutieres Syndrome (AGS). In doing so, the team was able to identify unusual and surprising underlying genetic mechanisms that drive AGS and test strategies to inhibit the condition using existing drugs.

New 3D Imaging Reveals How Human Cell Nucleus Organizes DNA and Chromatin of its Genome

July 27, 2017

A team of researchers at the University of California San Diego School of Medicine and the Salk Institute for Biological Studies describe development and application of new electron microscopic imaging tools and a selective stain for DNA to visualize the three-dimensional structure of chromatin — a complex of molecules that helps pack six feet of DNA into each cell nucleus, construct chromosomes and control gene expression and DNA replication.

CIRM Approves $5.8 Million Grant for CAR-T Therapy that Targets Cancer Stem Cells

July 20, 2017

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine (CIRM) today unanimously approved a $5.8 million award to University of California San Diego School of Medicine researchers to develop a new immunotherapy in which patients’ cells would be equipped with a special receptor that recognizes and targets cancer stem cells, whose survival abilities often render standard therapies ineffective or short-term.

Harnessing Cancer’s Methylation Footprint for More Precise Diagnosis and Prognosis

June 27, 2017

In a new study, researchers at University of California San Diego School of Medicine, with colleagues in Xijing Hospital and Sun Yat-sen Cancer Center in China, report that DNA methylation can provide effective markers for at least four major cancers, not only correctly differentiating malignant tissues from normal, but also providing information on prognosis and survival.
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