UC San Diego researchers have discovered an unexpected mechanism that allows bacteria to defend themselves against antibiotics, a finding that could lead to retooled drugs to treat infectious diseases.
New research reveals that foreign honey bees often account for more than 90 percent of pollinators observed visiting flowers in San Diego, a global biodiversity hotspot. The monopoly may strongly affect species that are foundational to the stability of the region’s plant-pollinator interactions.
UC San Diego researchers studying p53, the heralded cancer-fighting “guardian of the genome,” found that the human protein also plays a role in promoting tumors, in addition to suppressing them.
Using active genetics technology, biologists have developed the world’s first CRISPR/Cas9-based approach to control genetic inheritance in a mammal. The achievement in mice lays the groundwork for further advances based on this technology, including biomedical research on human disease.
Using CRISPR, researchers developed a way to suppress insects, including those that ravage crops and transmit deadly diseases. The technology alters genes for sex determination and fertility. When eggs are introduced, only sterile males emerge, resulting in a low-cost method of controlling pests.
UC San Diego scientists have been granted $2 million to develop new methods for manufacturing products based on algae. Biologist Stephen Mayfield will lead efforts to develop novel platforms to produce biologically based monomers that will be used to manufacture renewable and biodegradable products.
Biologists at UC San Diego have discovered a new way of re-sensitizing drug-resistant human tumor cells to the potency of DNA-damaging agents, the most widely used group of cancer drugs. In a new study, they describe how a human gene known as Schlafen 11 controls the sensitivity of tumor cells to DDAs.…
Scientists have known that bacteria produce small spherical versions of themselves. Lacking basic materials to reproduce or function like normal cells, the natural role of minicells—which protrude like budding balloons off the ends of bacteria—has remained a mystery. Now, researchers at UC San Diego…
UC San Diego biologists and their colleagues have revealed that enhancer RNAs play a significant role in cancer dissemination. The researchers found that eRNAs have a direct role in the activation of genes that are important for tumor development. This role is facilitated by the ability of eRNAs to directly…
A concept known as “percolation” is helping microbiologists at UC San Diego explain how communities of bacteria can effectively relay signals across long distances. Once regarded as simple clusters of microorganisms, communities of bacteria have been found to employ a strategy we use to brew coffee…