Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. In a new study, UC San Diego researchers found that opioid dependence produced permanent changes in the brains of rats.
Researchers say a gene known to be a biomarker of age plays a key role in age-associated functional and anatomical aging in mouse retinas, a finding that has direct relevance to age-related eye diseases.
Using novel imaging technologies, researchers produce first whole-brain atlas at single-cell resolution, revealing how alcohol addiction and abstinence remodel neural physiology and function in mice.
Researchers report that accumulating amyloid protein occurred faster among persons deemed to have "objectively-defined subtle cognitive difficulties" (Obj-SCD) than among persons considered to be "cognitively normal," offering a potential new early biomarker for Alzheimer's disease.
Novel spinal therapy/delivery approach prevented disease onset in neurodegenerative ALS disease model in adult mice and blocked progression in animals already showing disease symptoms.
Spontaneous mutations in male sperm are linked to development of autism spectrum disorder. Researchers have created a way to measure mutations and estimate risk of ASD in future children. If developed into a clinical test, the method could be a useful predictive tool in genetic counseling.
Two researchers at University of California San Diego School of Medicine—Pamela L. Mellon and Aleem Siddiqui—have been named Fellows of the American Association for the Advancement of Science (AAAS), the largest general science organization in the world and publisher of the journal Science.
UC San Diego researchers describe how circular extrachromosomal DNA in cancer cells boosts aggressiveness and resistance to therapies.
The Center for Medicinal Cannabis Research at University of California San Diego School of Medicine announces $3 million in research grants to explore new applications of cannabis for a number of novel medical applications.
Researchers at UC San Diego say they are getting closer to identifying the mechanisms of autism spectrum disorder, revealing a critical gene network that is disrupted and which helps predict severity of symptoms.